If preparing the Cajun spice blend, combine all the ingredients in a small bowl, then set it aside.

Pat dry catfish fillets after rinsing.

Season the fish fillets liberally on both sides, pushing spice into the flesh as necessary.

In a skillet, heat butter, olive oil, or both over medium-high heat.

Place the catfish in the skillet and let it cook for 5–6 minutes without moving. Cook the fillets for an additional five minutes on the other side. When fully cooked and done, the exterior will be slightly crispy and the flesh will be white. Fish should be cooked to an internal temperature of 145 °F.