Turn on the 375 degree oven. In a food processor, pulse bread until it is powdered. There ought to be roughly 2 1/2 cups of breadcrumbs. To a medium bowl, transfer.
Brush on meat after blending the brown sugar and remaining 1/2 cup of ketchup until smooth. A center-inserted instant-read thermometer should read 160 degrees after one hour and 20 minutes of baking the pan on a rimmed baking sheet. Allow to gently cool.
Brush meat with the mixture after thoroughly combining the brown sugar and remaining 1/2 cup of ketchup. Pan should be placed on a rimmed baking sheet. Bake for 1 hour and 20 minutes, or until an instant-read thermometer inserted in the center registers 160 degrees. Allow to cool a bit.